ABSTRACT
An unusual case of suicidal nitric acid ingestion is being reported in a 24 year-old factory worker, with classical postmortem features of xanthoproteic reaction and necrotic perforation of stomach.
ABSTRACT
Accidental poisoning of workers occurs occasionally in chemical and pharmaceutical industries. Some of the chemicals involved in industrial poisoning are unique and rarely available to the general public. One such case of poisoning due to dimethyl sulphate fumes is described. Death due to this poison has been rarely reported in literature. The respiratory and gastrointestinal systems are its primary targets. The diagnosis and prevention of this poisoning is of paramount importance.
ABSTRACT
This study was designed to determine the nitric oxide metabolism measured as circulating nitrate levels in the serum of alcoholic patients. Nitric oxide (NO) plays a significant role in the inflammatory process and has been implicated in several autoimmune disorders. This study was carried out prospectively to estimate the levels of nitrate in the serum, as a surrogate marker of NO production, among alcohol-dependent patients. Serum nitrate concentrations as an index of plasma NO levels were assessed in alcohol-dependent patients attending the deaddiction centre of a major hospital. Total sample size comprised 450 males. Age- and sex-matched non-alcoholic control population (n=90) was compared with alcoholics (n=360) of similar socioeconomic status. Serum nitrate concentration was assayed spectrophotometrically. Stable metabolites of nitrates were significantly higher in alcoholics compared with their nonalcoholic controls (p<0.05). The results may support the involvement of oxidative damage due to high NO concentration, and may be linked to its excitotoxicity and cytotoxicity in neurons, glia, and myelin. Generation of NO has been linked to an increased tendency towards tolerance to alcohol.
ABSTRACT
Butorphanol poisoning is not common. A case is presented of ingestion of toxic dose of butorphanol, which proved fatal in a young adult. Although the exact amount ingested could not be ascertained, the circumstances and observations pointed clearly to death due to overdose by butorphanol.
ABSTRACT
A case is reported of a young child being bitten by multiple fire ants, and succumbing. This is one of the rarest cases reported in literature.
ABSTRACT
Formaldehyde is an eye, skin, and respiratory tract irritant. Inhalation of vapour can produce narrowing of the bronchi and pneumonia. Liquid formalin causes corrosion of mucosa of the gastrointestinal tract. Systemic effects of formaldehyde are primarily due to conversion to formic acid and may include metabolic acidosis, circulatory shock, and acute renal failure. We report a case of accidental ingestion of formalin in an aquaculture research student.
ABSTRACT
foi realizado um estudo multicentrico aberto e nao comparativo, visando avaliar a eficacia terapeutica e a tolerancia de um potente antiinflamatorio, o complexo B-ciclodextrina piroxicam, no tratamento de patologias ortopedicas e reumaticas.O esquema posologico usado foi de uma capsula de 20 mg ao dia durante sete dias. O estudo foi desnvolvido em 14 centros de pesquisa por cerca de 1.500 medicos, distribuidos por todo o Brasil, envolvendo um total de3729 pacientes. A avaliacao global da eficacia clinica obteve em 93,1 por cento dos casos resultados considerados pelos medicos participantes como excelentes e bons (3472 pacientes). A tolerabilidade global evidenciou resultados excelentes e bons em 93,7 por cento dos casos (3495 pacientes); sendo que houve necessidade de interromper o tratamento em apenas 1,4 por cento dos casos (60 pacientes), devido a intensidade da reacao adversa. A intensidade da dor foi avaliada pelos medicos e pacientes imediatamente antes do tratamento e no 3§ e 7§ dia de tratamento; em ambos os controles a avaliacao estatistica usando o teste "t" de Student ("t" pareado) mostrou uma diminuicao da intensidade da dor altamente significante estatisticamente (p=~O). Diante destes resultados podemos concluir que o complexo B-ciclodextrina piroxicam* e eficaz e seguro como antiinflamatorio, no tratamento das patologias traumaticas e reumatologicas